Nelson Mandela University's Medical School, established in March 2021, is situated at the Missionvale Campus in Gqeberha. This strategic location places students in the heart of under-resourced communities, aligning with the institution's commitment to socially accountable and community-focused medical education. 

The Medical School offers a six-year MBChB (Bachelor of Medicine and Bachelor of Surgery) degree, emphasising comprehensive primary health care and leveraging technology to enhance learning. An inter-professional education model encourages collaboration among medical students and other health science disciplines, fostering a holistic approach to healthcare delivery. While specific demographic data for the Medical School's student body is not publicly available, the broader university community is known for its diversity and inclusivity. Students at the Medical School have access to a range of student societies and activities, promoting personal growth and community engagement.

Through this integrated approach, Nelson Mandela University's Medical School aims to produce competent, compassionate, and community-oriented doctors.