The Missionvale Campus is located along Johnson Road in the Missionvale area, within reach of communities such as Zwide and New Brighton.

It is easily accessible on the main thoroughfare between Gqeberha (formerly Port Elizabeth) and Kariega (formerly Uitenhage), a location identified as a major growth area by the Nelson Mandela Bay Metropolitan Municipality.

Due to its physical location in the more under-served and poorest areas of the Nelson Mandela Bay Metropolitan, Missionvale Campus is strategically positioned to engage with the communities in its surrounds.

The development initiatives established on the Campus aim to build strong and meaningful partnerships between the university and the communities within its vicinity.